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While most people are aware that they should not become pregnant while on a GLP-1, it is less well known that tirzepatide may affect the absorption of the oral contraceptive pill

Once GLP-1 is released, the peptide acts on GLP-1 receptors (GLP-1Rs) that are widely distributed in peripheral tissue, including the gut, stomach, pancreas, kidneys, heart, adipose cells, bones, and blood vessels (Vrang and Larsen, 2010